Targeted Protein
Degradation Forum
in Japan At Shonan iPark
August 22 - 23 , 2019

Day1 10:30~18:30 (Session+Exhibition)
18:30~20:00 (Dinner party)
Day2 10:00-15:00 (Session+Exhibition)
15:00-18:00 (Partnering+Exhibition)

Targeted Protein Degradation (TPD) is emerging technology. TPD is well known as Proteolysis Targeting Chimeras (PROTACs), the bi-functional molecules composed target binder with E3 ligase binder to hijack ubiquitin-proteasome system (UPS). In addition, Molecular Glue also lead to degrade the targeted proteins. Unlike conventional inhibitors, TPD has a potential to achieve the Drugging Undruggable Targets. Arvinas announced the initiation of first clinical trials of PROTACs drugs in this year. Now, researchers around the world are interested in TPD area. Therefore, this is very attractive event in terms of the deep discussion, networking with KOLs and business partnering among Academia, Pharma and service providers. Would you share your interest topic for the panel discussion?
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SPEAKERSClick on photos for more details

PROGRAM

Download program file

9:30

Registration

10:30-10:45

Opening remarks

10:45-11:30

Key noteInduced protein degradation by chimeric small molecules; recent progress and outlook

Mikihiko NaitoChief, Division of Molecular Target and Gene Therapy Products, National Institute of Health Sciences

11:30-12:00

PresentationRaPPIDS: Efficient discovery platform of the targeted protein degradation drugs

Yusuke TominariCEO/CSO, Co-Founder FIMECS, Inc.

12:00-12:15

iPark company session

SEED SUPPLY Inc.

12:30-13:00

Luncheon seminar

Carna Biosciences,Inc.

13:00-13:30

Networking break

13:30-14:00

PresentationMolecular mechanisms of cereblon-based drugs

Takumi ItoAssociate Professor Department of Nanoparticle Translational Research Tokyo Medical University

14:00-14:30

PresentationAutophagy-based targeted degradation

Hirokazu ArimotoProfessor Graduate School of Life Sciences Tohoku University

14:30-15:00

PresentationUSP8-STAM1 deubiquitinating enzyme complex is a novel drug target for Cushing's disease

Toshiaki FukushimaAssistant Professor Cell Biology Center Institute of Innovative Research Tokyo Institute of Technology

15:00-15:30

Networking break

15:30-16:00

KeynoteLeveraging the dTAG platform to degrade cancer dependencies

Behnam NabetResearch Fellow Dana-Farber Cancer Institute

16:00-16:30

Key noteThe Auxin-Inducible-Degron System as a Tool for Target Validation

Masato KanemakiProfessor National Institute of Genetics

16:30-17:00

Networking break

17:00-17:15

iPark company session

Axcelead Drug Discovery Partners, Inc.

17:15-18:30

iPark tour

iPark/Axcelead Drug Discovery Partners, Inc.

18:30-20:00

Dinner party

9:00

Registration

10:00-10:45

A platform approach for developing E3 ligase inhibitors or effectors for cancer therapy

Gwenn M. HansenSenior Vice President, Research Nurix Therapeutics

10:45-11:15

PresentationSulfonamide Small Molecules Target DCAF15-CUL4 Ubiquitin Ligase to Promote Selective Degradation of Splicing Factor CAPER-alpha

Taisuke UeharaPrincipal Scientist Eisai Co., Ltd.

11:15-11:45

Inhibiting DUBs for Targeted Protein Degradation

Benedikt KesslerProfessor of Biochemistry and Life Science Mass Spectrometry University of Oxford, UK

12:00-12:30

Luncheon seminar

WuXi AppTec

12:30-13:00

Networking break

13:00-13:30

Key noteUbiquitin mediated small molecule induced target elimination (uSMITE) for cancer

Michael PleweVice President - Medicinal Chemistry Cullgen Inc.

13:30-14:00

Key noteTargeted IRAK-M degradation as a novel approach in cancer immunotherapy overcoming innate-driven immunosuppression

Kanae GamoVP Biology Co-Founder FIMECS, Inc.

14:00-14:45

Panel discussion

14:45-14:55

Closing remarks

15:00-18:00

Partnering

Location

health-innovation-park

Access

Air Transportation

There are two major airports in the Tokyo region: Tokyo International Airport, Haneda (airport code: HND) and Narita International Airport (airport code: NRT).
These airports offer multiple Japan and international flights daily.

By Train

From JR Ofuna Station Bus: Take the Enoden bus bound for Fujisawa Station Kitaguchi (East Exit bus terminal, bus stop No.2) to Shonan iPark stop (Approx. 15 -30 mins)
Taxi: After exiting through the South Exit, take Taxi from West side taxi terminal (Approx. 10 mins)

From JR Fujisawa Station Bus: Take the Enoden bus bound for Ofuna Station Higashiguchi (North Exit bus terminal, bus stop No.9) to Shonan iPark stop (Approx. 15 mins)
Taxi: After exiting through the North Exit, take Taxi from West side terminal (Approx. 10 mins)

Access map Down load

REGISTRATION FEE

Payment received From July 20,2019
Full Conference Package
(Attendance in All Sessions and exhibition, Lunch (2Day), Dinner (day1)
JPY50,000
Academia・iPark tenant JPY40,000

This event has been closed.
Thank you very much for coming to Targeted Protein Degradation Forum in Japan.

Contact

Targeted Protein Degradation Forum in Japan (ibma,Co.,Ltd)
Mail:summit@ibtool.jp